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A human has been injected with gene-editing tools to cure his disabling disease. Here’s what you need to knowA human has been injected with gene-editing tools to cure his disabling disease. Here’s what you need to know

first_img By Jocelyn KaiserNov. 15, 2017 , 6:00 PM A human has been injected with gene-editing tools to cure his disabling disease. Here’s what you need to know AP Photo/Eric Risberg For the first time, researchers have infused a person’s blood with gene-editing tools, aiming to treat his severe inherited disease, The Associated Press (AP) reported today. The 44-year-old patient has a rare metabolic disorder called Hunter syndrome. But how big is the advance—and what does it mean for using hot new technologies such as CRISPR to help people with other genetic diseases?How does the treatment work?Hunter syndrome results from a mutation in a gene for an enzyme that cells need to break down certain sugars. When the enzyme is defective or missing, the sugars build up and can cause developmental delays, organ problems, brain damage, and early death. Brian Madeux, the first patient in what will be a small clinical trial has a mild form of the disease, but nevertheless has had more than two dozen operations as a result, AP reports.Someday, researchers may be able to use gene editing to repair the flawed gene in cells that causes diseases like Hunter syndrome. However, that’s not the goal of the trial, sponsored by Sangamo Therapeutics, a biotech company based in Richmond, California. Instead, the company inserts a replacement copy of the gene, using gene editing to snip the DNA helix of liver cells in a specific place near the promotor, or on-off switch, for the gene for a protein called albumin. The cells fix the damage by inserting the DNA for the new gene, supplied by the researchers along with the gene editor’s DNA scissors, and the gene’s activity is then controlled by the powerful albumin promotor. The idea is to turn these modified liver cells into a factory for making the enzyme missing in Hunter syndrome.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)Sangamo’s targeted approach, known as “safe harbor,” should avoid the risks of using traditional gene therapy to alter a cell’s genome, which pastes in the new gene at a random place in the genome and can potentially turn on a cancer gene. And because the body doesn’t need much of the enzyme, modifying just a small fraction of the liver’s cells should be enough to treat the disease.Although Hunter syndrome patients often receive weekly infusions of the missing enzyme, their blood levels drop within a day, says Sangamo CEO Sandy Macrae. The hope is that the one-time gene-editing treatment—given as a 3-hour intravenous infusion—will allow the liver to keep making the enzyme at a steady rate for years. There is a caveat, however: The enzyme Hunter patients now receive does not cross the blood-brain barrier, the tight network of cells that protects the brain from pathogens, and the livermade enzyme produced by the gene edit may not either. So the new treatment may not stop the brain damage that can occur in Hunter syndrome.Is this the first gene-edited human?Not quite. The trial is using a form of DNA scissors called zinc finger nucleases (ZFNs). Like the newer gene-editing technology CRISPR, ZFNs can cut both strands of the genome’s double DNA helix at a specific location. In trials several years ago, Sangamo used ZFNs to protect patients from HIV by harvesting their blood cells, disrupting a gene in them while growing in culture, and then transfusing the cells back into the patients.However, this is the first time ZFNs have been used directly to modify DNA in living patients—so-called in vivo gene editing. This is more complicated than editing cell’s DNA in a lab dish. For one thing, researchers must use a viral vector to ferry DNA encoding the ZFNs and the new gene into the liver cells. Although this virus, called adeno-associated virus, is widely used in gene therapy and is considered safe, it can trigger a potentially dangerous immune response in some patients—usually managed with steroids.And in vivo gene editing poses additional risks. Similar to the problem of traditional gene therapy hitting the wrong spot, ZFNs could make cuts in places where they weren’t supposed to and turn on a cancer gene. Compounding this risk, the liver cells that now contain the DNA for ZFNs will keep making the nucleases for perhaps years, even though they are no longer needed to guide the new gene to its spot in the genome. Sangamo’s Macrae says the company is confident that off-target cutting will be rare and would mainly occur in nonfunctioning stretches of DNA between genes. Virologist Marie-Louise Hammarskjold, who sat on a National Institutes of Health panel that approved the strategy, agrees that the safety data are convincing. “They had pretty good evidence, based on animal and cell culture experiments, that the off-target effects wouldn’t be such a high risk that [the trial] was not worth trying,” says Hammarskjold, who is at the University of Virginia School of Medicine in Charlottesville.Investigators will check for off-target effects by taking liver biopsies from some patients and looking for DNA changes, Macrae says. Even if the tests don’t find anything of concern, however, they could miss a cancerous cell somewhere in a patient’s liver that years from now will grow into a tumor, cautions gene therapy researcher Mark Kay of Stanford University in Palo Alto, California.What’s next?Sangamo is also testing the liver-factory gene treatment in trials now getting underway for the blood-clotting disorder hemophilia B and another metabolic disease, Hurler syndrome. “Once you show that this works and there are no horrible side effects, you could try it with many other diseases” by swapping out the inserted gene, Hammarskjold says. “That’s the big hope in this case. You don’t have to reinvent the wheel every time.” Brian Madeux, who has Hunter syndrome, has received a treatment aimed at editing the genome of his liver cells. last_img read more


first_img“Talks are going really well. They (Pacquiaos team) are “Talks are going really well. They (Pacquiaos team) are speaking to my team, I have just left it to my team. I fight anybody who is brought in front of me. If its Manny Pacquiao, its Manny Pacquiao if not then somebody else. But we are still waiting for response on whats going to happen. Thats why I took a little break and came to India just to get away from all that because negotiating for a fight is not easy,” he said. The prodigal talent, who has held the WBA and IBF light welterweight world titles, is also well-known for his charitable work in strife-torn nations, including Pakistan where he has his roots. “We have the Amir Khan Foundation which is huge now. I never expected it to be that big. Its growing quickly and all the money goes towards helping people. We are building orphanages in Africa, in fact around the world. We are feeding the homeless in UK. We are doing work in Pakistan too and we are keen to branch out to any other place where we are needed. We are there to help,” he said. Khan said in the larger scheme of things, sport could be the answer that the world is looking for to end strife. “Sport helps everything in the world, sport breaks barriers, stops war. If you go to any Championship in the world, you would see, India, Pakistan, England, in fact everybody united. Thats what you want. We want more people involved in sport because it brings everybody together,” he said. “If you cannot keep sport and politics separate then you can look at it this way that having everybody together is making everyone get along and helping them work together. Obviously they are different aspects but sport is the way forward in life. If you can channel your children and youth into sport, it will break all barriers,” Khan said. PTI PM CM CMadvertisementlast_img read more

Toyota to launch new Touring Sport variant of the Innova Crysta in AprilToyota to launch new Touring Sport variant of the Innova Crysta in April

first_imgJapanese carmaker Toyota is going to launch the Innova Crysta Touring Sport in India next month. This new variant is already on sale in the Indonesian market under the name of Venturer.The new variant will feature cosmetic upgrades to increase the appeal of Toyota’s highly popular MPV. It will have black plastic cladding on the front bumper, wheel arches and side skirts to give it a more rugged look. Chrome has also been splashed around graciously on the front grille and the ORVMs. The wheels are the same 16-inch alloys that are offered on the regular car but the one on the Touring Sport variant will be offered in black.Also Read:Toyota Corolla Altis facelift set for March 15 launchThe interiors of the car will be the same as the regular Innova Crysta other than the floor mats that are exclusively designed for the car. The car will be offered exclusively as a six-seater and the equipment levels will be the same as the current top-specced ZX variant.There will be no changes in the powertrain options and the Innova Crysta Touring Sport will be offered with the same engine and gearbox setups that are present on the regular Innova Crysta.Aldo Read: Hyundai Tucson vs Toyota Innova Crystalast_img read more

Sri Lanka set to begin packed India Tour from November 16Sri Lanka set to begin packed India Tour from November 16

first_imgSri Lanka will be playing three Tests, three ODIs and three T20Is over a period of 37 days on their tour to India.The first Test is likely to begin in Kolkata on November 16.The other two Tests will be played in Nagpur and Delhi before the limited-overs leg of the tour kicks off in Dharamsala with the first ODI to be played on December 10.The remaining two ODIs will be played in Mohali and Visakhapatnam. The two sides will then lock horn in the three T20Is which are slated to be held in Cuttack, Indore and Mumbai.The official tour itinerary is, however, still yet to be announced by the BCCI.ESPNcricinfo has verified the schedule with most of the hosting centres.”We were initially supposed to host Sri Lanka in December and Odisha [Cuttack] were supposed to host the New Zealand game in November,” Kerala Cricket Association secretary Jayesh George said.”But, there is a festival in Odisha in November, so we are now hosting the New Zealand game instead,” he added.India would be high on confidence when they face Sri Lanka in their den, considering they defeated their Asian neighbours 9-0 across all three formats on their away tour in July-August.India v Sri Lanka fixtures:1st Test: November 16-20, Kolkata2nd Test: November 24-28, Nagpur3rd Test: December 2-6, Delhi1st ODI: December 10, Dharamsala2nd ODI: December 13, Mohali3rd ODI December 17, Visakhapatnam1st T20I: December 20, Cuttack2nd T20I: December 22, Indore3rd T20I: December 24, Mumbaiadvertisementlast_img read more

Cristiano Ronaldo hits out at rape allegations: ‘It goes against everything I am’Cristiano Ronaldo hits out at rape allegations: ‘It goes against everything I am’

first_imgCristiano Ronaldo has strongly denied an accusation of rape made against him by Kathryn Mayorga, claiming such a crime was “against everything that I am and believe in”.Mayorga says she was assaulted by the footballer after they met at a Las Vegas nightclub in 2009. In an interview with the German magazine Der Spiegel last weekend she gave extensive details of her claims. Ronaldo responded on Wednesday on Twitter, saying he awaits the results of a reopened police investigation “with tranquillity”. Share on Facebook Share via Email Cristiano Ronaldo Share on Pinterest At the time Ms Mayorga reported the alleged assault in 2009 she refused to name her assailant. She later initiated a legal process that resulted in a financial settlement being agreed between both parties. The terms of that settlement included Mayorga not going public with her claims but the 34-year-old teacher, under new legal advice, now believes the settlement to be void and has spoken out.“At the time the report was taken, the victim did not provide detectives with the location of the incident or suspect description,” said a statement from the Las Vegas police on Monday. “As of September 2018, the case has been reopened and our detectives are following up on information being provided.” Read more Share on WhatsApp Topics news Cristiano Ronaldo rape allegation: police reopen investigation into 2009 claim Share on LinkedIn Cristiano Ronaldo (@Cristiano)I firmly deny the accusations being issued against me. Rape is an abominable crime that goes against everything that I am and believe in. Keen as I may be to clear my name, I refuse to feed the media spectacle created by people seeking to promote themselves at my expense.October 3, 2018 Share on Messenger Share on Twitter “I firmly deny the accusations being issued against me,” Ronaldo said. “Rape is an abominable crime that goes against everything that I am and believe in. Keen as I may be to clear my name, I refuse to feed the media spectacle created by people seeking to promote themselves at my expense.“My clear conscious [sic] will thereby allow me to await with tranquillity the results of any and all investigations.”Lawyers for Mayorga, who sued Ronaldo in a district court in Clark County, Nevada, said the Portugal forward has 20 days from the filing of the lawsuit to respond. Mayorga alleges that Ronaldo raped her in 2009 in a Las Vegas hotel penthouse suite.Mayorga had been emboldened to speak out because of the #MeToo movement, her lawyers said at a news conference on Wednesday. “The #MeToo movement and the women who have stood up and disclosed sexual assaults has given Kathryn a lot of courage,” attorney Leslie Stovall said.Her lawyers added that Mayorga has left Las Vegas to escape the attention on her case, adding the alleged assault has caused her severe mental and emotional damage. She was not at the news conference.“She has decided not to make herself available to the media and stay out of the public because of her emotional state,” Stovall said. “It is not pleasant for her.” Her lawyers added they are considering whether to release documents they say relate to the case including police reports, medical records, and an out-of-court settlement that apparently included a non-disclosure agreement about the incident. They claimed that a psychiatrist has determined she suffers post-traumatic stress and depression because of the alleged 2009 attack in Las Vegas.Ronaldo has previously described Ms Mayorga’s allegations as “fake news”. His latest remarks follow the decision by the Las Vegas police authorities this week to conduct further investigations into the claims. Reuse this contentlast_img read more

India vs New Zealand, World Cup semifinal Live Streaming: Watch reserve day on Star Sports, DD SportsIndia vs New Zealand, World Cup semifinal Live Streaming: Watch reserve day on Star Sports, DD Sports

first_img Next India Today Web Desk Agra and New DelhiJuly 10, 2019UPDATED: July 10, 2019 11:31 IST India vs New Zealand, World Cup 2019 semi-final reserve day: How to watch liveRain stopped play in the first semifinal between India and New Zealand at the Old Trafford on Tuesday with the Kiwi scoreboard reading 211/5 after 46.1 overs. New Zealand will resume their innings on Wednesday on the same score with 23 balls of their innings still remaining.Ross Taylor was unbeaten on 67 off 85 balls when the umpires decided the players needed to head back to the pavilion.As per the rain rules of the International Cricket Council for the semifinals and the final, the umpires must try to complete the match on the scheduled match day by using the available extra time (120 minutes) and by reducing the number of overs down to a minimum of 20 overs per team in order to achieve a result.If there is still no result on the scheduled match day, play will continue on the reserve day, using the same start time and hours of play as the scheduled match day. The reserve day will be a continuation, not a restart. Any advantage earned on the scheduled day will be carried through to the reserve day.A tied match will use a super over to determine the winner. If the semifinal doesn’t reach a result even after the scheduled day and the reserve day, the higher placed team from the league stage will progress to the final, which in this case will be India.What TV channel is the World Cup 2019 semi-final match India vs New Zealand on?All World Cup 2019 matches can be viewed on – Star Sports 1, Star Sports 2, Star Sports 3, Star Sports 1 in Hindi, Star Sports HD and DD Sports.advertisementWhere will the World Cup 2019 semi-final match India vs New Zealand played?The World Cup 2019 match India vs New Zealand will resume at Old Trafford in Manchester from 3 PM IST on Wednesday, July 9.Where can I watch the World Cup 2019 semi-final match India vs New Zealand live?The match will be shown on the Star Sports TV network and DD Sports.Where can I check the online live updates of the World Cup 2019 semi-final match between India and New Zealand?You can follow our coverage here – are the playing 11s for the World Cup 2019 semi-final match India vs New Zealand?India: KL Rahul, Rohit Sharma, Virat Kohli (c), Rishabh Pant, Hardik Pandya, MS Dhoni (wk), Dinesh Karthik, Bhuvneshwar Kumar, Ravindra Jadeja, Jasprit Bumrah, Yuzvendra ChahalNew Zealand: Martin Guptill, Henry Nicholls, Kane Williamson (c), Ross Taylor, Tom Latham (wk), James Neesham, Colin de Grandhomme, Mitchell Santner, Lockie Ferguson, Matt Henry, Trent BoultAlso See:For sports news, updates, live scores and cricket fixtures, log on to Like us on Facebook or follow us on Twitter for Sports news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byAkshay Ramesh Tags :Follow India vs New ZealandFollow World Cup 2019Follow India cricket teamFollow Semi-finalFollow Virat KohliFollow Rohit SharmaFollow Trent Boult India vs New Zealand, World Cup semifinal Live Streaming: Watch reserve day on Star Sports, DD SportsIndia vs New Zealand, World Cup 2019 semifinal on reserve day in Manchester: Here’s how you can watch IND vs NZ live on TV, online on Wednesday. Rain forced the 1st semi-final into the reserve day. advertisementlast_img read more

Emerson to Provide UPS Systems for Shell’s Prelude FLNG …Emerson to Provide UPS Systems for Shell’s Prelude FLNG …

first_img My location Print  Close 此页面无法正确加载 Google 地图。您是否拥有此网站?确定 zoom Emerson Network Power, a business of Emerson (EMR) has been selected as the main uninterruptible power supply (UPS) systems provider for Shell’s Prelude FLNG project.The company will help provide reliable standby power for critical process functions, such as the main automation systems, fire and gas detection systems, and telecommunications. Emerson’s Chloride industrial-grade UPS systems are designed to supply backup power in the most demanding environments for a lifetime of more than 20 years.“Mission-critical facilities on Shell’s FLNG facility require the highest levels of availability, and backup power supplies are key components of making sure infrastructure like this remains always-on,” said Scott Barbour, business leader for Emerson Network Power. “This is a great opportunity for us to join our colleagues at Emerson Process Management to put some of our best solutions and services into practice, in an extraordinary application.”In 2010, Emerson Process Management, another global business of Emerson, was selected as the Main Automation Contractor for the Shell Prelude development.Shell’s Prelude FLNG project, the world’s first floating liquefied natural gas (FLNG) project, is currently under construction in Korea for deployment to the Browse Basin off the coast of Western Australia. Emerson, January 17, 2014last_img read more

Transport News Brief – Wednesday 2 January 2008Transport News Brief – Wednesday 2 January 2008

93 Oscar Pistorious wants, controversially, to compete in the next Olympics. What’s all the fuss forHe is a double amputee and would run on two artificial ‘legs’ 81 Who played 21 live gigs at the O2 Arena last summerPrince 73 What is the name of the sea between Australia and New ZealandThe Tasman Sea. 86 An albino bird made it to the pages of British newspapers this week. What species was itA robin 38 What is a micronOne millionth of a metre. Its symbol is the Greek letter ?. 27 Who was appointed director of MI5 in April ’07John Evans 69 What is Alan Bennett’s latest book calledAn Uncommon Reader 70 Which credit card firm has just been ordered to withdraw an illegal fees schemeMasterCard 42 What date is Easter Monday on in 200824 March 19 Whose boots were made for walkingNancy Sinatra’s 35 When was Harvard University founded1636 53 Who is the new prime minister of the UkraineYulia Tymoshenko 46 When, over the 2007 Christmas period, is the full moonChristmas Eve, 24 December. 41 Which airline was the first to fly the Airbus 380 ‘super jumbo’Singapore Airlines 8 Who won this year’s Templeton Prize, at £800,000, the richest in the worldProfessor Emeritus sharks Taylor, political science at McGill university. 12 What was the first jet airliner in commercial service in 1952The De Havilland Comet 45 Who founded the British Labour Party, in 1893Kier Hardie 66 Which coroner is presiding over the latest inquest into Princess Diana’s deathLord Justice Scott Baker. 84 The mayor of which city plans to tax fizzy, sugary drinks to help fund the treatment of obesitySan Francisco 62 What was the name of the operation to invade Iraq in 1991Operation Desert Storm. 11 When did British troops first deploy to Northern Ireland1969 22 What did Britain recognise with the Treaty of Paris in 1783The United States of America 49 Who holds the record as England’s second oldest monachQueen Victoria, record was broken by the present Queen on 20 December this year. 15 Who famously killed herself by clasping an asp to her breastCleopatra 31 Who, in the 1950s, said it was too early to tell the result of the French RevolutionChou en Lai, prime minister of the People’s Republic of China. 67 For how long may the UK police hold a suspect terrorist without charging them28 days 39 Which politician’s statue was unveiled in Parliament Square, London, recentlyNelson Mandela. 26 Where is the longest champagne bar in EuropeSt Pancras Station, London 98 Who said ‘If you have to tell them who you are, you aren’t anybody’Gregory Peck 91 Which country’s government just resolved a six-month row over languageBelgium, where Flemish-speaking Flemings and French-speaking Walloons did a deal to form a government 16 Who was the lead guitarist in the ShadowsHank Marvin 57 In what year was Anne Boleyn sent to the Tower of London1536 40 What is a antiphonA type of hymn, sung as a response. 34 Why does the UK tax year start on 6 AprilIt used to start on Lady Day, 25 March, but a change to the Gregorian calendar cut 11 days off the year. 18 Which claims to be Europe’s busiest stationClapham Junction. 36 When did the Marie Celeste sail from New York1871 58 Who is the England rugby team’s head coachBrian Ashton 51 Who won the 2007 Eurovision Song ContestSerbia, with Marija _erifovi? singing ‘Molitva’ 13 Who wanted to be Bobby’s GirlMarcie Blane, in 1962 33 Who, reputedly, had the longest entry in Who’s WhoBarbara Cartland 56 Who just won the leadership of South Africa’s ANCJacob Zuma 48 What is a Vulture FundAn outfit that buys the debt, usually of poor, developing countries and then sues the debtor for much more. 61 How many Red Letter Days are there now in Great Britain25 28 Where and when did the first Woolworth’s open in the UKIn Liverpool, in 1909 10 Who, in 1908, made the first powered flight in the UKSam Cody, who was killed in a flying accident in 1913 6 What notorious poison did the EU outlaw this yearStrychnine 4 What and where is the oldest free-standing glass house in the worldThe Temperate House, at the Royal Botanic Gardens, Kew. 20 When did the UK Ministry of Transport publish its first Highway Code1931 23 What is an opsimathOne who learns late in life 63 Who won the 2007 Man Booker Prize for literatureAnne Enright, with The Gathering 47 When did Abba take Waterloo to No 1 in the UKMay 1974 71 In which two countries are the Atlas mountainsAlgeria and Morroco 97 Sotherby’s in New York just sold a 13th century copy of what for $21.3mThe Magna Carta 55 Who wrote Fanny HillJonathan Cleland 32 What is the most obvious visual difference between a soprano saxophone and lower tone modelsA soprano sax is straight, while most lower-tone saxophones have a characteristic U bend. 29 Which was the BBC’s first local radio stationRadio Leicester, which first broadcast on Thursday 8 November 1967 30 What were the traditional colours the British Suffragette movementPurple and green 37 What was particularly unusual about the 1912 Oxford and Cambridge Boat RaceBoth boats sank 59 In writing, how should you address a bishopDear Bishop 60 What is a Red Letter DayA day of such civil or ecclesiastical importance that it was marked in red on early religious calendars. 17 What was Luciano Pavrotti’s fist jobHe was a school teacher 88 The fossil of a small deer-like animal from India seems to be an ancestor of which living mammalsWhales 1 Who was the first model to make it to the pages of Who’s WhoKate Moss 64 How many states are there in AustraliaSix and three mainland territories 43 Who took Great Balls of Fire to No 1 in 1958Gerry Lee Lewis 44 In which year did the UK’s Open University award its first degrees1973 14 When did the US annex New Mexico1846 68 Which of Canada’s states stretches furthest southOntario 24 When was the UK £1 note withdrawn1984 76 What has Japan agreed not to kill just yetHumpback whales 96 The EU’s Schengen agreement for a passport-free zone just got nine new members. What is the total now24 72 When did the UK and France sign the Entent Cordiale1904 99 Filming for a new James Bond film is to start in early January. What will it be calledBond 22 74 Who has Time magazine named as Person of the Year for 2007Vladimir Putin 100 Which EU country just banned stag hunting from horsebackIrelandClick to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window) 75 Who is Carla Bruni dating nowNicolas Sarkozy, president of France 77 Which ballet is running at Sadler’s Wells until 20 January 2008Matthew Bourne’s Nutcracker! 78 What is name the for the piece of water between the Scottish mainland and the Isles of SkyeThe Sound of Sleat 21 Which confederate general’s surrender ended the American Civil War in 1865Robert E Lee 80 Kalaallit Nunaat is the inhabitant’s name for which very large island in the Northern HemisphereGreenland 85 Who is the new face of Chanel No 5Nicole Kidman 82 What, according to Schott, is the nickname for a pre-pubescent girl, dressed in a sexually provocative wayProstitot 83 Who owns Liverpool Football ClubAmericans Tom Hicks and George Gillett Jnr 2 What is misfeasanceDoing something legal in an illegal way 65 What is the biggest island in the Indian OceanMadagascar 94 Who wrote Fahrenheit 451Ray Bradbury 87 Who got a red card as Chelsea beat Liverpool recentlyPeter Crouch 50 When did the UK join the Common Market1973 89 Which livestock disease made its debut in England last summerBluetongue 95 Kenny Richey is to return to the UK after 21 years in the US. What was he doing thereHe was on death row 54 Which big London hotel just closed for a year-long makeoverThe Savoy 92 Which of Ealing Studio’s schools is back on the screenSt Trinians 5 Who published the first recipe for curry in EnglandHannah Glasse – in Glasse’s Art of Cookery in 174. Her ‘currey’ contained only pepper and coriander. 79 Britannia was the UK’s last Royal Yacht. When was she launched1953 9 Who invented Mother’s Day, as we now know itAnna Jarvis, in the USA. 90 For which paper does Lucy Kellaway writeThe Financial Times, for which she is the management columnist 52 Who just bought more than £1,000’s worth of spoons from the Savoy memorabilia saleYuri Geller 25 Which musical gave us the song The Age of AquariusHair 7 Which daughter of a Russian aristocrat won a Oscar recentlyHelen Mirren, born Ilnynea Lydia Mironoff, whose father was forced to leave by the Russian Revolution. 3 What, according to the Oxford English dictionary is the most common noun in the English languageTime read more

Android Market gets its own web storeAndroid Market gets its own web store

first_imgDuring the Android 3.0 event it was announced that Android Market is getting a convenient, cloud-based web store. It’s available for use right now at site works on your computer but will work even better on your Android device. Here is will coordinate with the Android Market app, which is more convenient to use and already has all your credentials stored. That said, you will be able to buy an app on your computer (or any internet-capable device) and get in on your Android device from there.One new feature with the Market that was announced today was currency support. This means that publishers will be able to set prices for their apps in a given currency if they don’t want to set a price in a single currency and use a conversion rate for the others.Test it out at, though it does not seem to be possible to login yet.Update: Google explains everything in their blog post:The website makes it easy to discover great new apps with a bigger, brighter interface. You can also send apps directly to your Android device with just a few clicks—no wires needed. We’ve built in new social features, too. You can share apps with your friends through Twitter. And you can read and post app reviews directly to Android Market from the web or from your device. And what about all those apps you’ve already purchased and downloaded? Sign in to the website with your Google account and click “My Market Account” to see all the apps you’ve purchased or downloaded. It makes managing all your apps quite easy.last_img read more

Man hangs himself after attempting to kill his wifeMan hangs himself after attempting to kill his wife

first_imgBy Louise JobeMomodou Sowe, a resident of Mandinary village in the Kombo North District, has committed suicide by hanging himself, after his attempt to chop off the head of his wife, with a machete.This horrible incident, happened on Sunday 18th June 2017, between the hours of 7pm and 9pm when he attempted to kill his wife.According to sources, the deceased requested for some water from his wife after breaking his fast, who in turn gave the water to the daughter to take to the father; that by this time the deceased had the cutlass hidden under his arm pit; that after he drank the water, he gave the cup to his daughter to return it to the mother; that without any notice, the deceased quickly rushed on the wife by pulling his cutlass from his under arm pit and suddenly hacked her on her shoulder; that this was the first attempt; that when the wife realized that she was hacked and wounded, she stood to defend herself and that was when the deceased hacked her again for the second time, wounding her on both hands.Eyewitnesses further said that it was at this moment, that the deceased, Momodou Sowe, ran immediately into the bush and hanged himself with a rope. When the neighbours arrived at the scene, they quickly contacted the Mandinary Police who came and rushed the seriously wounded wife to Banjulunding Major Health for medical attention and later to Serrekunda General Hospital, where she is currently admitted for treatment.The police spokesperson when contacted, confirmed the story and indicated that Momodou Sowe attempted to kill the wife with a cutlass and this landed on the wife’s neck and some parts of her fingers .He also said that the deceased, Momodou Sowe, committed suicide and his body was at the mortuary; that the wife is presently admitted at the Serrekunda General Hospital, where she is receiving treatment. PRO Conta concluded that the Police will conduct investigation on the matter but that this cannot proceed now because the woman is still at the hospital and they have to wait for her, whilst she recuperates.last_img read more

EEOC sues Burgers Beer for sex discriminationEEOC sues Burgers Beer for sex discrimination

first_img KUSI Newsroom SAN DIEGO (KUSI) – The U.S. Equal Employment Opportunity Commission filed a lawsuit Thursday in San Diego alleging that Burgers & Beer, a chain of Southern California restaurants, violated federal law by denying male applicants and employees the same employment opportunities as their female counterparts.The EEOC alleges that since at least 2015, the company routinely rejected male applicants and employees for server positions and maintained a server workforce that was more than 90 percent female, in violation of Title VII of the Civil Rights Act of 1964, which prohibits discrimination on the basis of sex.Burgers & Beer, which according to its website has restaurants in six locations, including Temecula, Yuma and El Centro, did not immediately respond to a request for comment.The EEOC said it filed the lawsuit after first attempting to reach a pre-litigation settlement through its conciliation process. The EEOC is seeking injunctive relief to prohibit Burgers & Beer from engaging in future alleged unlawful discrimination on the basis of sex, as well as compensatory and punitive damages for the victims.“Denying someone the chance to compete for a job simply because of their gender violates federal law, even if the employer presumes customers would prefer to be surrounded by female servers,” said Christopher Green, director of the EEOC’s San Diego office. “Presumed preferences are no excuse for any kind of discrimination. The EEOC will continue to pursue the eradication of this type of unlawful behavior.” August 30, 2018 KUSI Newsroom, EEOC sues Burgers & Beer for sex discrimination Posted: August 30, 2018 Categories: Local San Diego News FacebookTwitterlast_img read more

October trial to decide custody of autistic boysOctober trial to decide custody of autistic boys

first_imgThe permanent custody of two autistic boys who were reportedly held captive in a cagelike room will be decided at an Oct. 7 trial.In the meantime, the boys, ages 6 and 7, will stay in foster care, Clark County Superior Court Commissioner Carin Schienberg decided at a Tuesday hearing.Assistant Attorney General Dana Gigler said there was “no substantial change in circumstances” warranting a shift in the boys’ care. Currently, the boys are staying in foster homes in Clark County; two other boys of the father, John Eckhart, and his live-in girlfriend, Alayna Higdon, are staying with family members. The two autistic boys are now enrolled in schools in Clark County, a Department of Social and Health Services spokeswoman said.The autistic boys’ biological mother, Jona Bronson, lives in Tillamook, Ore., and is seeking permanent custody. She has been allowed visitation at a DSHS office; a no-contact order is in place for Eckhart in connection to his criminal case.Bronson was not present for Tuesday’s hearing, but her Vancouver attorney appeared on her behalf.Eckhart, 30, and Higdon, 26 were arrested April 12 after Vancouver police found the boys in a dark, mostly empty bedroom with a door and window covered with wire shelving similar to those used in closets. The boys were still in diapers, not enrolled in school and couldn’t speak, police said.An apartment maintenance worker at the complex on Northeast 66th Avenue, Springfield Meadows, became aware of the situation during a routine premises check and notified police.last_img read more

3YearOld Child Fatally Shoots Himself In Anchorage Home3YearOld Child Fatally Shoots Himself In Anchorage Home

first_imgOfficials say a 3-year-old boy shot and killed himself inside an Anchorage home.Download AudioPolice received a call just after noon on Wednesday reporting the shooting at a home in southeast Anchorage. The child was pronounced dead at the scene.Investigators concluded the child fatally shot himself with a gun he found inside the home.No charges have been filed, but the case has been sent to the District Attorney’s Office for review. There were three adults in the home at the time of the shooting.last_img read more

Arun Jaitley Lists Out Economic Problems Promises Solutions ahead of Union BudgetArun Jaitley Lists Out Economic Problems Promises Solutions ahead of Union Budget

first_imgFinance Minister Arun Jaitley said that the government would focus on fiscal prudence over “mindless populism” for the Union Budget to be presented on 10 July.”If you indulge in mindless populism you burden the exchequer… you convert yourself into a high taxation society. It does not work. Therefore if you have to follow a path of fiscal prudence, (you should) have a certain amount of discipline,” Jaitley said, while addressing a function at the Institute of Chartered Accountants of India (ICAI) on Tuesday.Jaitley said that the main challenges for the new government was that of a high fiscal deficit, high inflation and the impact of the Iraq crisis on the economy, Press Trust of India reported.Here are some of the issues Jaitley addressed and gave solutions for:Challenge: Attracting InvestmentJaitley said that the world suspects that India does not have a stable tax regime which in itself has dissuaded investors. He touched the issue of “tax terrorism.”  “Just as policy paralysis was unknown to our governance vocabulary, the other new addition which I have been reading comments from independent observers…is tax terrorism,” he said. Solution: Bold Decisions, Overall ImprovementJaitley hinted at making “bold decisions” to improve the credibility of the Indian economy. He said that there is now hope in the investment scenario after four years of pessimism, and that “bold decision-making is now possible.”He also gave an all-round solution to improve economic credibility and bring in investment. “Your infrastructure should be supportive, your decision making has to be quicker, your taxation regime has to be reasonable and the prospect of profitability has to be there,” he said.Challenge: Rain Deficit and Food InflationThe late monsoons have caused food inflation to reach almost 10 percent, with the prices of onions rising rather steeply because of artificial scarcity. Jaitley said that though the rate of inflation (wholesale price index-based) was lower than last year, it was still “beyond the acceptable limit.” WPI-based inflation went up to 6.01 percent in May.Solution: ManagementWhile the Centre is already taking steps to deter artificial scarcity by asking states to crack down on hoarders, Jaitley said that management is the key to check food price rise. “We have a huge amount of food. We have no scarcity and we are in a position to manage it. I think if we decide to go on that path, growth rates are going to pick up,” he said.Challenge: Fiscal Deficit Citing fiscal deficit, which stood at 45 percent of the budget estimate in the months of April and May, Jaitley said that it was an impediment to growth. “Fiscal deficit is a major challenge. The growth has slowed down,” he said. Solution: Fiscal Discipline Jaitley pressed for fiscal discipline to check fiscal deficit. “Now India needs certain amount of fiscal discipline, and there is hope that bold decisions will be taken now,” Jaitley said.last_img read more

UN to take part in Rohingya repatriation ShahriarUN to take part in Rohingya repatriation Shahriar

first_imgShahriar AlamBangladesh has signed a deal to involve the United Nations in the controversial process of returning Rohingya refugees to Myanmar, a minister said Monday.Junior foreign minister Shahriar Alam said the government was involving the UN refugee agency so that it could not be accused of sending anyone from the stateless Muslim minority back against their will.He gave few details, but said refugees would be asked to fill out repatriation forms in the presence of UN officials.Bangladesh reached a deal with Myanmar late last year to repatriate the nearly 700,000 Rohingya who have fled across the border since August to escape a brutal military crackdown.That was meant to start last month, but was delayed by a lack of preparations and protests by Rohingya refugees, most of whom say they do not wish to return without guarantees of safety.”We have repeatedly said this repatriation process is very complex,” Alam told reporters.”We want to fill up the (repatriation) forms in their (UN) presence so that no one can say they been forced by someone or sent back against their will,” he told reporters at a Rohingya refugee camp in Bangladesh’s southeastern border district of Cox’s Bazar.There was no immediate comment from the UN, which has said previously that any repatriation must be voluntary.Alam urged patience and said Bangladesh did not want to send back the refugees only to have them return, as has happened after past rounds of repatriation.Bangladesh “wants to make sure the situation in Myanmar is safe and secure”, he said.Refugees are still entering Bangladesh with claims of rights abuses by Buddhist mobs and the military.Many have lost their homes to arson attacks in their native Rakhine state, where witnesses and rights groups say entire Rohingya settlements have been burned to the ground.New arrivals have brought harrowing tales of rape, murder and torture.The Rohingya also want guarantees of citizenship before returning to Myanmar, which views them as illegal immigrants from Bangladesh even though many have been there for generations.last_img read more

Exboyfriend burns Indian woman to deathExboyfriend burns Indian woman to death

first_imgA father and son have been arrested in India for allegedly burning a woman alive over a soured relationship, authorities said Monday.The 18-year-old was beaten by her former boyfriend and his father before being doused in kerosene and set alight in a district of Rajasthan state in western India, police said.“She was attacked by the father-son duo and later burnt alive,” local police officer Manish Charan told AFP.He said the woman was returning home when the pair accosted her late Saturday in a local market.The ex-lover poured kerosene on the victim, but she was unsure who set her ablaze, the officer said quoting her dying statement.She died from severe burns in hospital on Sunday.The woman’s family has accused the man of stalking her after the couple broke up some time ago.Reported crimes against women have risen dramatically in India in recent years and particularly following the brutal gang rape and murder of a 23-year-old woman in New Delhi in 2012.In a neighbouring Rajasthan district on Sunday, a 70-year-old woman was beaten to death by a villager who accused her of witchcraft.last_img read more

PM Hasina calls on China to convince Myanmar to take Rohingyas backPM Hasina calls on China to convince Myanmar to take Rohingyas back

first_imgChinese Ambassador to Bangladesh Zhang Zuo met prime minister Sheikh Hasina at her Sangsad Bhaban office in Dhaka on Tuesday. Photo: PIDPrime minister Sheikh Hasina on Tuesday urged China to persuade Myanmar so that they take back their over one million Rohingya nationals from Bangladesh.The prime minister made the request when Chinese Ambassador to Bangladesh Zhang Zuo met her at her Sangsad Bhaban office, reports news agency UNB.The prime minister’s press secretary Ihsanul Karim briefed newsmen after the meeting.He said the prime minister expressed again her firm stance over the Rohingya issue saying that the displaced people have to go back to their homeland.The Chinese Ambassador said China will play a constructive role in resolving the Rohingya issue.Meanwhile, Beijing has invited prime minister Hasina to pay an official visit to China from 1 to 5 July.The Chinese government also invited the prime minister to attend the annual meeting of the “New Champions” which is known as “Summer Davos” to be held in Dalian on 1-3 July.It will be Sheikh Hasina’s first bilateral visit to Beijing following her party’s overwhelming victory in the last parliamentary elections.She will have meetings with president Xi Jinping and prime minister Li Keqiang during the crucial visit.The press secretary further said the prime minister and the Ambassador also discussed the prime minister’s China visit.Hasina said four instruments on bolstering bilateral cooperation between Bangladesh and China will be signed during her visit to China.Both the prime minister and the envoy expressed satisfaction over the existing bilateral relations between the two nations and hoped that the ties will be further strengthened in the days to come.The Chinese envoy said the Dhaka-Beijing relations reached a new height after the visit of their president Xi Jinping to Bangladesh in 2016.About Dhaka-Beijing bilateral cooperation, Hasina mentioned that the construction work on Karnaphuli Tunnel in Chattogram is going on with Chinese support.Knowing that a book on the China visits of Bangabandhu Sheikh Mujibur Rahman will be published, the Ambassador showed his country’s interest to translate it into Chinese language.In this regard, the prime minister urged the envoy to give the photographs on the visits of Bangabandhu, if they have any.The prime minister’s principal secretary Md Nojibur Rahman was present on the occasion.last_img read more

What Are The Priorities For The Legislatures Special SessionWhat Are The Priorities For The Legislatures Special Session

first_img Share Nicolas Henderson/FlickrTexas State Capitol in Austin.The Texas Legislature begins a special session today (July 18, 2017). Gov. Greg Abbott has called lawmakers back for a 30-day legislative overtime to address some issues he sees as a priority.Those priorities include everything from legislation to extend the life of state licensing agencies, to revisiting the so-called “bathroom bill,” to raising teacher pay, to regulating trees on private land. Legislators have already filed more than 100 bills.Joining us to get an overview of what will be on the agenda – and how the special session works – are Mark Jones of Rice University’s Baker Institute for Public Policy, and Ross Ramsey, executive editor at The Texas Tribune.Toward the end of the regular session. Lt. Governor Dan Patrick threatened to force a special session, refusing to bring up sunset legislation in the Senate unless the House passed property tax relief and a bathroom bill. But Gov. Abbott controls the agenda for the special session. Under his timeline, the Senate has to pass a sunset bill before the legislature can deal with anything else.Every Texas state agency carries an expiration date. The Legislature has to vote every few years to extend the agency’s life. Five of these were still awaiting action when the regular session ended – among them, the Texas Medical Board.Special Coverage Of The 85th Texas Legislative Session“You can’t have medicine being practiced in the state without state oversight,” says Joey Longley, former director of the Texas Sunset Advisory Commission. He says the medical board will begin shutting down September 1 unless lawmakers act soon. “It can’t happen. You’ve got Medicaid reimbursements. There’s all sorts of things that go into that. Not to mention malpractice and liability. The list is too great to enumerate.”Other agencies that need sunset legislation to keep their doors open include the Texas State Board of Examiners of Psychologists, the Texas State Board of Examiners of Marriage and Family Therapists, the Texas State Board of Examiners of Professional Counselors, and the Texas State Board of Social Worker Examiners.MORE: Sunset Bill Top Priority For Special Session (News 88.7, July 17, 2017) Lawmakers File Dozens Of Bills For Special Session (Texas Tribune, July 10, 2017) Abbott’s Aggressive Approach To Special Session (Texas Tribune, June 22, 2017) Critics: Gov. Catering To Donors In Special Session (Texas Tribune, July 14, 2017)last_img read more